Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP

• Autores principales: Yao Zhang (Autor), Yilan Teng (Autor), Wangwen Xiao (Autor), Beiying Xu (Autor), Ya Zhao (Autor), Weihua Li (Autor), Ligang Wu (Autor)
• Formato: Libro
• Publicado: Elsevier, 2020-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Recently, the US Food and Drug Administration (FDA) approved the first small interfering RNA (siRNA) drug, marking a significant milestone in the therapeutic use of RNA interference (RNAi) technology. However, off-target gene silencing by siRNA remains one of the major obstacles in siRNA therapy. Al...