Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer's Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways

• Main Authors: Xinhua Zhou (Author), Zeyu Zhu (Author), Shaoming Kuang (Author), Kaipeng Huang (Author), Yueping Li (Author), Yuqiang Wang (Author), Haiyun Chen (Author), Maggie Pui Man Hoi (Author), Benhong Xu (Author), Xifei Yang (Author), Zaijun Zhang (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a neurodegenerative disorder associated with age. A wealth of evidence indicates that the amyloid β (Aβ) aggregates result from dyshomeostasis between Aβ production and clearance, which plays a pivotal role in the pathogenesis of AD. Consequently, therapies targeting...