The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain

• Principais autores: Hsin-Hui Hsieh (Autor), Yen-An Chen (Autor), Yao-Jen Chang (Autor), Hsin-Hui Wang (Autor), Ya-Han Yu (Autor), Sheng-Wei Lin (Autor), Yin-Jung Huang (Autor), Steven Lin (Autor), Ching-Jin Chang (Autor)
• Formato: Livro
• Publicado em: BMC, 2021-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, and its mRNA destabilization activity is regulated by protein phosphorylation. Methods We ge...