The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain

• Main Authors: Hsin-Hui Hsieh (Author), Yen-An Chen (Author), Yao-Jen Chang (Author), Hsin-Hui Wang (Author), Ya-Han Yu (Author), Sheng-Wei Lin (Author), Yin-Jung Huang (Author), Steven Lin (Author), Ching-Jin Chang (Author)
• Format: Book
• Published: BMC, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, and its mRNA destabilization activity is regulated by protein phosphorylation. Methods We ge...