Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors

• Main Authors: Daniel eClayton (Author), Iresha eHanchapola (Author), Walter Glen Thomas (Author), Robert eWiddop (Author), Alexander Ian Smith (Author), Patrick ePerlmutter (Author), Marie-Isabel eAguilar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7. This conversion inactivates the vasoconstrictive...