Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor

• Main Authors: Aya Soudi (Author), Onur Bender (Author), Ismail Celik (Author), Amer Ali Abd El-Hafeez (Author), Rumeysa Dogan (Author), Arzu Atalay (Author), Eslam B. Elkaeed (Author), Aisha A. Alsfouk (Author), Elshimaa M. N. Abdelhafez (Author), Omar M. Aly (Author), Wolfgang Sippl (Author), Taha F. S. Ali (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein kinases regulate cellular activities and make up over 60% of oncoproteins and proto-oncoproteins. Among these kinases, FLT3 is a member of class III receptor tyrosine kinase family which is abundantly expressed in individuals with acute leukemia. Our previous oxindole-based hit has a particu...