All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK Signaling Pathway

• Main Authors: Jingzhi Zhang (Author), Bo Deng (Author), Xiaoli Jiang (Author), Min Cai (Author), Ningning Liu (Author), Shuangwei Zhang (Author), Yongzhen Tan (Author), Guiqiong Huang (Author), Wen Jin (Author), Bin Liu (Author), Shiming Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The proliferation and migration of vascular smooth muscle cells (VSMC) is extensively involved in pathogenesis of neointimal hyperplasia. All-trans-retinoic acid (ATRA) is a natural metabolite of vitamin A. Here, we investigated the involvement of AMP-activated protein kinase (AMPK) in the anti-neoi...