Oxaliplatin(IV) Prodrugs Functionalized with Gemcitabine and Capecitabine Induce Blockage of Colorectal Cancer Cell Growth-An Investigation of the Activation Mechanism and Their Nanoformulation

• Main Authors: Carlo Marotta (Author), Damiano Cirri (Author), Ioannis Kanavos (Author), Luisa Ronga (Author), Ryszard Lobinski (Author), Tiziana Funaioli (Author), Chiara Giacomelli (Author), Elisabetta Barresi (Author), Maria Letizia Trincavelli (Author), Tiziano Marzo (Author), Alessandro Pratesi (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of platinum-based anticancer drugs, such as cisplatin, oxaliplatin, and carboplatin, is a common frontline option in cancer management, but they have debilitating side effects and can lead to drug resistance. Combination therapy with other chemotherapeutic agents, such as capecitabine and ge...