A Single Nucleotide Variant in HNF-1β is associated with Maturity-Onset Diabetes of the Young in a Large Chinese Family

• Main Authors: Peng ZHOU (Author), Ran WEI (Author), Zhenkui GUO (Author), Haining ZHU (Author), Desmond CAMPBELL (Author), Qi LI (Author), Xiaoqun XU (Author), Junfu WANG (Author), Meng LUAN (Author), Xing CHEN (Author), Gang CHEN (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Maturity-onset diabetes of the young (MODY) is a heterogeneous entity of monogenic disorders characterized by autosomal dominant inheritance. Eleven genes were related, including HNF4α, GCK, HNF1α, IPF1, and HNF-1β, and various mutations are being reported. Methods: To help the overall u...