Repeated exposure to Lutzomyia intermedia sand fly saliva induces local expression of interferon-inducible genes both at the site of injection in mice and in human blood.

• Main Authors: Tiffany Weinkopff (Author), Camila I de Oliveira (Author), Augusto M de Carvalho (Author), Yazmin Hauyon-La Torre (Author), Aline C Muniz (Author), Jose Carlos Miranda (Author), Aldina Barral (Author), Fabienne Tacchini-Cottier (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During a blood meal, Lutzomyia intermedia sand flies transmit Leishmania braziliensis, a parasite causing tegumentary leishmaniasis. In experimental leishmaniasis, pre-exposure to saliva of most blood-feeding sand flies results in parasite establishment in absence of any skin damages in mice challen...