Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.

• Main Authors: André Luiz Leturiondo (Author), Ariani Batista Noronha (Author), Carla Yael Ribeiro Mendonça (Author), Cynthia de Oliveira Ferreira (Author), Lucia Elena Alvarado-Arnez (Author), Fernanda Saloum de Neves Manta (Author), Ohanna Cavalcanti de Lima Bezerra (Author), Elizeu Fagundes de Carvalho (Author), Milton Ozório Moraes (Author), Fabíola da Costa Rodrigues (Author), Carolina Talhari (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leprosy is a chronic infectious disease, caused by Mycobacterium leprae, which affects skin and peripheral nerves. Polymorphisms in genes associated with autophagy, metabolism, innate and adaptive immunity confer susceptibility to leprosy. However, these associations need to be confirmed through ind...