Cepharanthine inhibits influenza A virus replication by impairing viral polymerase activity and regulating influenza-induced immune response

• Main Authors: Yinyan Li (Author), Huiting Sang (Author), Qinxian Mo (Author), Linrui Jiang (Author), Zhixuan Chen (Author), Jinlong Liang (Author), Chunyu Zhang (Author), Zhengyin Zhang (Author), Chenglai Xia (Author), Jie Yang (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Cepharanthine (CEP), a natural bis-benzylisoquinoline alkaloid extracted from the plant Stephania cephalantha Hayata, has been widely used to treat several acute and chronic diseases. However, its antiviral potential against influenza A virus (IAV) infection remains unknown. Purpose: The...