Cepharanthine inhibits influenza A virus replication by impairing viral polymerase activity and regulating influenza-induced immune response

• Egile Nagusiak: Yinyan Li (Egilea), Huiting Sang (Egilea), Qinxian Mo (Egilea), Linrui Jiang (Egilea), Zhixuan Chen (Egilea), Jinlong Liang (Egilea), Chunyu Zhang (Egilea), Zhengyin Zhang (Egilea), Chenglai Xia (Egilea), Jie Yang (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2024-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background: Cepharanthine (CEP), a natural bis-benzylisoquinoline alkaloid extracted from the plant Stephania cephalantha Hayata, has been widely used to treat several acute and chronic diseases. However, its antiviral potential against influenza A virus (IAV) infection remains unknown. Purpose: The...