Functions of IgM fc receptor (FcµR) related to autoimmunity

• Main Authors: Hiromi Kubagawa (Author), Pedram Mahmoudi Aliabadi (Author), Khlowd Al-Qaisi (Author), Peter K. Jani (Author), Kazuhito Honjo (Author), Shozo Izui (Author), Andreas Radbruch (Author), Fritz Melchers (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractUnlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, w...