Excretion of the Polymyxin Derivative NAB739 in Murine Urine

• Главные авторы: Martti Vaara (Автор), Timo Vaara (Автор), Janis Kuka (Автор), Eduards Sevostjanovs (Автор), Solveiga Grinberga (Автор), Maija Dambrova (Автор), Edgars Liepinsh (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2020-03-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Extremely multiresistant strains of Enterobacteriaceae are emerging and spreading at a worrisome pace. Polymyxins are used as the last-resort therapy against such strains, in spite of their nephrotoxicity. We have previously shown that novel polymyxin derivatives NAB739 and NAB815 are less nephrotox...