Combining data on the bioavailability of midazolam and physiologically‐based pharmacokinetic modeling to investigate intestinal CYP3A4 ontogeny

• Asıl Yazarlar: Trevor N. Johnson (Yazar), Hannah K. Batchelor (Yazar), Jan Goelen (Yazar), Richard D. Horniblow (Yazar), Jean Dinh (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2024-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Pediatric physiologically‐based modeling in drug development has grown in the past decade and optimizing the underlying systems parameters is important in relation to overall performance. In this study, variation of clinical oral bioavailability of midazolam as a function of age is used to...