Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable Protective Immune Response in Hamsters.

• Main Authors: Jacqueline Araújo Fiuza (Author), Ranadhir Dey (Author), Dwann Davenport (Author), Maha Abdeladhim (Author), Claudio Meneses (Author), Fabiano Oliveira (Author), Shaden Kamhawi (Author), Jesus G Valenzuela (Author), Sreenivas Gannavaram (Author), Hira L Nakhasi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral leishmaniasis (VL) is a neglected tropical disease and is fatal if untreated. There is no vaccine available against leishmaniasis. The majority of patients with cutaneous leishmaniasis (CL) or VL develop a long-term protective immunity after cure from infection, which indicates that develop...