Formulation of Glibenclamide proniosomes for oral administration: Pharmaceutical and pharmacodynamics evaluation

• Main Authors: Doaa Alshora (Author), Mohamed Ibrahim (Author), Nouf Alanazi (Author), Malak Alowyid (Author), Zainab Ali Alnakhli (Author), Noura Mohammed Alshiban (Author), Saleh Maodaa (Author), Nouf M. Alyami (Author), Ibrahim Alotaibi (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glibenclamide (GB), oral antidiabetic sulfonylurea, is used in the management of diabetes mellitus type II. It suffers from low bioavailability due to low water solubility. This work aimed to enhance the dissolution of GB by formulating the drug as a proniosomes which then improves the pharmacologic...