Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice

• Main Authors: Yangchen Dhondup (Author), Ivar Sjaastad (Author), Øystein Sandanger (Author), Jan Magnus Aronsen (Author), Muhammad Shakil Ahmed (Author), Håvard Attramadal (Author), Alexandra Vanessa Finsen (Author), Lili Zhang (Author), Trine Ranheim (Author), Katrine Alfsnes (Author), Pål Aukrust (Author), Geir Christensen (Author), Arne Yndestad (Author), Leif Erik Vinge (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim. Inflammation is important in heart failure (HF). The role of the immune receptor toll-like receptor 9 (TLR9) in HF is not understood and not investigated in diastolic HF. We investigated the role of TLR9 in a murine diastolic HF model caused by cardiomyocyte SERCA2a excision. Methods and Result...