Class-IA Phosphoinositide 3-Kinase p110β Triggers GPCR-Induced Superoxide Production in p110γ-Deficient Murine Neutrophils

• Главные авторы: Kiyomi Nigorikawa (Автор), Kaoru Hazeki (Автор), Takashi Kumazawa (Автор), Yuhta Itoh (Автор), Megumi Hoshi (Автор), Osamu Hazeki (Автор)
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• Опубликовано: Elsevier, 2012-01-01T00:00:00Z.
• Предметы: article
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Studies with knockout mice have indicated that the only isoform of phosphoinositide 3-kinase (PI3K) functioning in the oxidative burst of mouse neutrophils in response to heterotrimeric guanine nucleotide-binding protein-coupled receptor (GPCR) agonists is a class-IB PI3K, p110γ. In the present stud...