Pharmacokinetics and pharmacodynamics of itepekimab in adults with moderate‐to‐severe atopic dermatitis: Results from two terminated phase II trials

• Main Authors: Matthew P. Kosloski (Author), Emma Guttman‐Yassky (Author), Michael J. Cork (Author), Margitta Worm (Author), Dong‐Ho Nahm (Author), Xiaoping Zhu (Author), Marcella K. Ruddy (Author), Sivan Harel (Author), Mohamed A. Kamal (Author), Hélène Goulaouic (Author), Christine R. Xu (Author), Elena Avetisova (Author), John D. Davis (Author), Michael C. Nivens (Author), Arsalan Shabbir (Author), Allen Radin (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Interleukin‐33 (IL‐33) is a proinflammatory alarmin cytokine released by damaged epithelial tissue cells that initiates and amplifies both type 1 and type 2 inflammatory cascades. A role for IL‐33 in atopic dermatitis (AD; a chronic, relapsing type 2 inflammatory disease of the skin) has be...