A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo

• Main Authors: Aaron Prodeus (Author), Amanda Sparkes (Author), Nicholas W. Fischer (Author), Marzena Cydzik (Author), Eric Huang (Author), Ismat Khatri (Author), Ashley Young (Author), Lindsay Woo (Author), Chung Wai Chow (Author), Reginald Gorczynski (Author), Jean Gariépy (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Functional aptamers displaying agonistic or antagonistic properties are showing great promise as modulators of immune responses. Here, we report the development of a polyethylene glycol-modified (PEGylated) DNA aptamer as a cross-species (murine and human) CD200R1 agonist that modulates inflammatory...