Utility of primary cells to examine NPC1 receptor expression in Mops condylurus, a potential Ebola virus reservoir.

• Main Authors: Marcel Bokelmann (Author), Kathryn Edenborough (Author), Nicole Hetzelt (Author), Petra Kreher (Author), Angelika Lander (Author), Andreas Nitsche (Author), Uwe Vogel (Author), Heinz Feldmann (Author), Emmanuel Couacy-Hymann (Author), Andreas Kurth (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The significance of the integral membrane protein Niemann-Pick C1 (NPC1) in the ebolavirus entry process has been determined using various cell lines derived from humans, non-human primates and fruit bats. Fruit bats have long been purported as the potential reservoir host for ebolaviruses, however...