Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.

• Main Authors: Claire D Bourke (Author), Norman Nausch (Author), Nadine Rujeni (Author), Laura J Appleby (Author), François Trottein (Author), Nicholas Midzi (Author), Takafira Mduluza (Author), Francisca Mutapi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Improved helminth control is required to alleviate the global burden of schistosomiasis and schistosome-associated pathologies. Current control efforts rely on the anti-helminthic drug praziquantel (PZQ), which enhances immune responses to crude schistosome antigens but does not prevent re-infection...