New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases

• Main Authors: Milena Mlakić (Author), Tena Čadež (Author), Danijela Barić (Author), Ivana Puček (Author), Ana Ratković (Author), Željko Marinić (Author), Kornelija Lasić (Author), Zrinka Kovarik (Author), Irena Škorić (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. The treatment comprises...