Berberine Alleviates Insulin Resistance and Inflammation via Inhibiting the LTB4-BLT1 Axis

• Main Authors: Minmin Gong (Author), Huiyan Duan (Author), Fan Wu (Author), Yanlin Ren (Author), Jing Gong (Author), Lijun Xu (Author), Fuer Lu (Author), Dingkun Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Chronic low-grade inflammation is recognized as a key pathophysiological mechanism of insulin resistance. Leukotriene B4 (LTB4), a molecule derived from arachidonic acid, is a potent neutrophil chemoattractant. The excessive amount of LTB4 that is combined with its receptor BLT1 can caus...