Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

• Egile Nagusiak: Kevin McNally (Egilea), Craig Sams (Egilea), Alex Hogg (Egilea), Annie Lumen (Egilea), George Loizou (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A physiologically based pharmacokinetic model for Di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the biokinetics in humans after single oral doses. The model was parameterized with in vitro and in silico derived parameters and uncertainty and sensitivity analysis was used during the...