Low-dose LBH589 increases the sensitivity of cisplatin to cisplatin-resistant ovarian cancer cells

• Main Authors: Yen-Ying Ma (Author), Hao Lin (Author), Jau-Sung Moh (Author), Kuang-Den Chen (Author), I-Wen Wang (Author), Yu-Che Ou (Author), Ying-Shu You (Author), Chia-Chi Lung (Author)
• Format: Book
• Published: Elsevier, 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: There is a need to develop alternative therapeutic strategies to overcome cisplatin-associated resistance in patients with ovarian cancer. Histone deacetylation (HDAC) associated with inactivation of genes has been implicated in the epigenetic silencing of tumor suppressor genes affecting...