A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer

• Main Authors: Yang Liu (Author), Xiaowei Zhang (Author), Ping Zhang (Author), Tingting He (Author), Weitao Zhang (Author), Dingyuan Ma (Author), Ping Li (Author), Jun Chen (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is discovered that activated caspase-3 tends to induce apoptosis in gasdermin E (GSDME)-deficient cells, but pyroptosis in GSDME-sufficient cells. The high GSDME expression and apoptosis resistance of pancreatic ductal adenocarcinoma (PDAC) cells shed light on another attractive strategy for PDAC...