Effects of Flow Hydrodynamics and Eye Movements on Intraocular Drug Clearance

• Main Authors: Angeliki Velentza-Almpani (Author), Nkiruka Ibeanu (Author), Tianyang Liu (Author), Christopher Redhead (Author), Peng Tee Khaw (Author), Steve Brocchini (Author), Sahar Awwad (Author), Yann Bouremel (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New in vitro prototypes (PK-Eye™) were tested with and without eye movement to understand diffusion and convection effects on intraocular clearance. Port placement in front ((i) ciliary inflow model) and behind the model lens ((ii) posterior inflow model) was used to study bevacizumab (1.25 mg/50 µL...