Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF)

• Main Authors: Philip Storck (Author), Florian Umstätter (Author), Sabrina Wohlfart (Author), Cornelius Domhan (Author), Christian Kleist (Author), Julia Werner (Author), Klaus Brandenburg (Author), Stefan Zimmermann (Author), Uwe Haberkorn (Author), Walter Mier (Author), Philipp Uhl (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The increasing number of infections caused by multidrug-resistant bacteria requires an intensified search for new antibiotics. Pep19-4LF is a synthetic antimicrobial peptide (GKKYRRFRWKFKGKLFLFG) that was previously designed with the main focus on high antimicrobial activity. The hydrophobic motif,...