Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties

• Main Authors: Caterina Pont (Author), Anna Sampietro (Author), F. Javier Pérez-Areales (Author), Nunzia Cristiano (Author), Agustí Albalat (Author), Belén Pérez (Author), Manuela Bartolini (Author), Angela De Simone (Author), Vincenza Andrisano (Author), Marta Barenys (Author), Elisabet Teixidó (Author), Raimon Sabaté (Author), M. Isabel Loza (Author), José Brea (Author), Diego Muñoz-Torrero (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multitarget compounds have emerged as promising drug candidates to cope with complex multifactorial diseases, like Alzheimer's disease (AD). Most multitarget compounds are designed by linking two pharmacophores through a tether chain (linked hybrids), which results in rather large molecules tha...