Transport and Biotransformation of Gliclazide and the Effect of Deoxycholic Acid in a Probiotic Bacteria Model

• Main Authors: Maja Ðanić (Author), Bojan Stanimirov (Author), Nebojša Pavlović (Author), Saša Vukmirović (Author), Jelena Lazić (Author), Hani Al-Salami (Author), Momir Mikov (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Introduction: Inter-individual differences in gut microflora composition may affect drug metabolism and overall therapeutic response. Gliclazide is a drug characterized by large inter-individual differences in therapeutic response; however, the causes of these differences are not fully explained and...