In vivo effects of bradykinin B2 receptor agonists with varying susceptibility to peptidases.

• Main Authors: Mélissa eJean (Author), Lajos eGera (Author), Xavier eCharest-Morin (Author), François eMarceau (Author), Hélène eBachelard (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We reported evidence of bradykinin (BK) regeneration from C-terminal extended BK sequences that behave as peptidase-activated B2 receptor (B2R) agonists. Further to these in vitro studies, we carried out in vivo experiments to verify hemodynamic effects of BK analogs exhibiting variable susceptibili...