Expression of drug transporters in the human skin: comparison in different species and models and its implication for drug development

• Главные авторы: Hanan Osman-Ponchet (Автор), Alexandre Gaborit (Автор), Jean-Michel Linget (Автор), Claire E. Wilson (Автор)
• Формат: ‌
• Опубликовано: International Association of Physical Chemists (IAPC), 2017-06-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

It is clear that many drug transporters (both ABCs and SLCs) are present in the human skin. Different in vitro skin models can be used to investigate the role of drug transporters in the skin despite quantitative differences in expression profile across species. P-gp was shown to have an important i...