BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis

• Main Authors: Li Jinteng (Author), Xu Peitao (Author), Yu Wenhui (Author), Ye Guiwen (Author), Ye Feng (Author), Xu Xiaojun (Author), Su Zepeng (Author), Lin Jiajie (Author), Che Yunshu (Author), Zhang Zhaoqiang (Author), Zeng Yipeng (Author), Li Zhikun (Author), Feng Pei (Author), Cao Qian (Author), Li Dateng (Author), Xie Zhongyu (Author), Wu Yanfeng (Author), Shen Huiyong (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During the aging process, the reduced osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) results in decreased bone formation, which contributes to senile osteoporosis. Previous studies have confirmed that interrupted circadian rhythm plays an indispensable role in age-related...