Phosphorothioate-Modified AP613-1 Specifically Targets GPC3 when Used for Hepatocellular Carcinoma Cell Imaging

• Main Authors: Lili Dong (Author), Hongxin Zhou (Author), Menglong Zhao (Author), Xinghui Gao (Author), Yang Liu (Author), Dongli Liu (Author), Wei Guo (Author), Hongwei Hu (Author), Qian Xie (Author), Jia Fan (Author), Jiang Lin (Author), Weizhong Wu (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glypican-3 (GPC3), the cellular membrane proteoglycan, has been established as a tumor biomarker for early diagnosis of hepatocellular carcinoma (HCC). GPC3 is highly expressed in more than 70% HCC tissues detected by antibody-based histopathological systems. Recently, aptamers, a short single-stran...