Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs....

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Main Authors: Mouli Chakraborty (Author), Chantal Sellier (Author), Michel Ney (Author), Villa Pascal (Author), Nicolas Charlet-Berguerand (Author), Ruben Artero (Author), Beatriz Llamusi (Author)
Format: Book
Published: The Company of Biologists, 2018-04-01T00:00:00Z.
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