Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis

• Main Authors: Hans I-Chen Harn (Author), Po-Yuan Chiu (Author), Chein-Hong Lin (Author), Hung-Yang Chen (Author), Yung-Chih Lai (Author), Fu-Shiuan Yang (Author), Chia-Ching Wu (Author), Ming-Jer Tang (Author), Cheng-Ming Chuong (Author), Michael W. Hughes (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the large full-thickness mouse skin regeneration model, wound-induced hair neogenesis (WIHN) occurs in the wound center. This implies a spatial regulation of hair regeneration. The role of mechanotransduction during tissue regeneration is poorly understood. Here, we created wounds with equal area...