A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples

• Κύριοι συγγραφείς: LaFramboise William A (Συγγραφέας), Lyons-Weiler Maureen A (Συγγραφέας), Chandran Uma R (Συγγραφέας), Lisovich Alex (Συγγραφέας), Brown Ashley R (Συγγραφέας), Jakacki Regina I (Συγγραφέας), Pollack Ian F (Συγγραφέας), Sobol Robert W (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: BMC, 2011-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Genomic instability in cancer leads to abnormal genome copy number alterations (CNA) as a mechanism underlying tumorigenesis. Using microarrays and other technologies, tumor CNA are detected by comparing tumor sample CN to normal ref...