A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples

• Main Authors: LaFramboise William A (Author), Lyons-Weiler Maureen A (Author), Chandran Uma R (Author), Lisovich Alex (Author), Brown Ashley R (Author), Jakacki Regina I (Author), Pollack Ian F (Author), Sobol Robert W (Author)
• Format: Book
• Published: BMC, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Genomic instability in cancer leads to abnormal genome copy number alterations (CNA) as a mechanism underlying tumorigenesis. Using microarrays and other technologies, tumor CNA are detected by comparing tumor sample CN to normal ref...