Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

The gut wall consists of many biological elements, including enterocytes. Rapid turnover, a prominent feature of the enterocytes, has generally been ignored in the development of enterocyte‐targeting drugs, although it has a comparable rate to other kinetic rates. Here, we investigated the impact of...

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Main Authors: Hiroyuki Takita (Author), Adam S. Darwich (Author), Amais Ahmad (Author), Amin Rostami‐Hodjegan (Author)
Format: Book
Published: Wiley, 2020-11-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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