Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

• Автори: Hiroyuki Takita (Автор), Adam S. Darwich (Автор), Amais Ahmad (Автор), Amin Rostami‐Hodjegan (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2020-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The gut wall consists of many biological elements, including enterocytes. Rapid turnover, a prominent feature of the enterocytes, has generally been ignored in the development of enterocyte‐targeting drugs, although it has a comparable rate to other kinetic rates. Here, we investigated the impact of...