Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice

• Main Authors: Insa Bultmann-Mellin (Author), Jeroen Essers (Author), Paula M. van Heijingen (Author), Harald von Melchner (Author), Gerhard Sengle (Author), Anja Sterner-Kock (Author)
• Format: Book
• Published: The Company of Biologists, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LTBP-4L and LTBP-4S are two isoforms of the extracellular matrix protein latent-transforming growth factor beta-binding protein 4 (LTBP-4). The mutational inactivation of both isoforms causes autosomal recessive cutis laxa type 1C (ARCL1C) in humans and an ARCL1C-like phenotype in Ltbp4−/− mice, bot...