Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

• Main Authors: Maxim Jestin (Author), Senta M. Kapnick (Author), Tatyana N. Tarasenko (Author), Cassidy T. Burke (Author), Patricia M. Zerfas (Author), Francisca Diaz (Author), Hilary Vernon (Author), Larry N. Singh (Author), Ronald J. Sokol (Author), Peter J. McGuire (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: In individuals with mitochondrial disease, respiratory viral infection can result in metabolic decompensation with mitochondrial hepatopathy. Here, we used a mouse model of liver-specific Complex IV deficiency to study hepatic allostasis during respiratory viral infection. Methods: Mice w...