Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

• 主要な著者: Maxim Jestin (著者), Senta M. Kapnick (著者), Tatyana N. Tarasenko (著者), Cassidy T. Burke (著者), Patricia M. Zerfas (著者), Francisca Diaz (著者), Hilary Vernon (著者), Larry N. Singh (著者), Ronald J. Sokol (著者), Peter J. McGuire (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2020-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: In individuals with mitochondrial disease, respiratory viral infection can result in metabolic decompensation with mitochondrial hepatopathy. Here, we used a mouse model of liver-specific Complex IV deficiency to study hepatic allostasis during respiratory viral infection. Methods: Mice w...