Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

Objective: In individuals with mitochondrial disease, respiratory viral infection can result in metabolic decompensation with mitochondrial hepatopathy. Here, we used a mouse model of liver-specific Complex IV deficiency to study hepatic allostasis during respiratory viral infection. Methods: Mice w...

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Main Authors: Maxim Jestin (Author), Senta M. Kapnick (Author), Tatyana N. Tarasenko (Author), Cassidy T. Burke (Author), Patricia M. Zerfas (Author), Francisca Diaz (Author), Hilary Vernon (Author), Larry N. Singh (Author), Ronald J. Sokol (Author), Peter J. McGuire (Author)
Format: Book
Published: Elsevier, 2020-07-01T00:00:00Z.
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3rd Floor Main Library

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