Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells

Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells

Multidrug resistance (MDR) is a leading cause for treatment failure in cancer patients. One of the reasons of MDR is drug efflux by ATP-binding cassette (ABC) transporters in eukaryotic cells especially ABCB1 (P-glycoprotein). In this study, certain novel 1,2,5-trisubstituted benzimidazole derivativ...

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Main Authors: Abeer H. A. Abdelhafiz (Author), Rabah A. T. Serya (Author), Deena S. Lasheen (Author), Nessa Wang (Author), Mansour Sobeh (Author), Michael Wink (Author), Khaled A. M. Abouzid (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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