Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.

• Main Authors: Dennis J Grab (Author), Jose C Garcia-Garcia (Author), Olga V Nikolskaia (Author), Yuri V Kim (Author), Amanda Brown (Author), Carlos A Pardo (Author), Yongqing Zhang (Author), Kevin G Becker (Author), Brenda A Wilson (Author), Ana Paula C de A Lima (Author), Julio Scharfstein (Author), J Stephen Dumler (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Using human brain microvascular endothelial cells (HBMECs) as an in vitro model for how African trypanosomes cross the human blood-brain barrier (BBB) we recently reported that the parasites cross the BBB by generating calcium activation signals in HBMECs through the a...