TGF-β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti- and Proliver Fibrosis

• Main Authors: Ai-Ting Yang (Author), Dou-Dou Hu (Author), Ping Wang (Author), Min Cong (Author), Tian-Hui Liu (Author), Dong Zhang (Author), Ya-Meng Sun (Author), Wen-Shan Zhao (Author), Ji-Dong Jia (Author), Hong You (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transforming growth factor-beta 1 (TGF-β1) plays a central role in hepatic progenitor cells- (HPCs-) mediated liver repair and fibrosis. However, different effects of TGF-β1 on progenitor cells have not been described. In this study, both in vitro (HPCs cocultured with hepatic stellate cells (HSCs)...