Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients

• Main Authors: Petr Kosztyu (Author), Martin Hill (Author), Jana Jemelkova (Author), Lydie Czernekova (Author), Leona Raskova Kafkova (Author), Miroslav Hruby (Author), Karel Matousovic (Author), Karel Vondrak (Author), Josef Zadrazil (Author), Ivan Sterzl (Author), Jiri Mestecky (Author), Milan Raska (Author)
• Format: Book
• Published: Karger Publishers, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular injury. In patients with active disease nonre...