Tipifarnib physiologically‐based pharmacokinetic modeling to assess drug-drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients

• मुख्य लेखकों: Noriko Okudaira (लेखक), Howard Burt (लेखक), Amitava Mitra (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract A physiologically‐based pharmacokinetic (PBPK) model for tipifarnib, which included mechanistic absorption, was built and verified by integrating in vitro data and several clinical data in healthy subjects and cancer patients. The final PBPK model was able to recover the clinically observed...