Personalized circulating tumor DNA analysis for sensitive disease monitoring and detection of relapse in neuroblastoma

• Main Authors: Ida Rahmqvist (Author), Enya Engström (Author), Elisabeth Mellström (Author), Raghda R. Ibrahim (Author), Fani Pujol-Calderón (Author), Agnes Dahlstrand Rudin (Author), Anna Ordqvist Redfors (Author), Niki Rostamzadeh (Author), Rita Di Rienzo (Author), Wilma Franssila (Author), Robert Khashan (Author), Moe Xylander (Author), Christin Karlsson (Author), Torben Ek (Author), Daniel Andersson (Author), Tobias Österlund (Author), Jennie Gaarder (Author), Henrik Fagman (Author), Susanne Fransson (Author), Tommy Martinsson (Author), Anders Ståhlberg (Author), Martin Dalin (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Circulating tumor DNA (ctDNA) has shown potential as a non-invasive tumor biomarker in neuroblastoma. Previous studies used generic assays for detection of selected predefined oncogenic variants as markers of ctDNA, which limits the sensitivity and excludes a subset of patients from analysi...