The Distinct Roles of Calmodulin and Calmodulin Kinase II in the Reversal of Run-Down of L-Type Ca2+ Channels in Guinea-Pig Ventricular Myocytes

• Egile Nagusiak: Li-Ying Hao (Egilea), Wu-Yang Wang (Egilea), Etsuko Minobe (Egilea), Dong-Yun Han (Egilea), Jian-Jun Xu (Egilea), Asako Kameyama (Egilea), Masaki Kameyama (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2009-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In this study, we investigated the roles of calmodulin kinase II (CaMKII) and calmodulin (CaM) in the reversal of run-down of L-type Ca2+ channels. Single Ca2+-channel activities in guinea-pig ventricular myocytes were recorded using the patch-clamp technique, and run-down of the channel activities...