Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?

• Main Authors: Baptiste Ameline (Author), Michal Kovac (Author), Michaela Nathrath (Author), Maxim Barenboim (Author), Olaf Witt (Author), Andreas H Krieg (Author), Daniel Baumhoer (Author)
• Format: Book
• Published: Wiley, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. More than a third of patients do not respond to standard therapy and urgently require alternative treatment options. Due to a high degree of inter‐ and intra‐tumoural genomic heterogeneity and complex...